Universitätsklinikum Schleswig-Holstein
Klinik für Allgemeine Pädiatrie
Arnold-Heller-Strasse 3, Haus 9
24105 Kiel
Germany

 www.uk-sh.de

Project Leader

Prof. Dr. Paul-Martin Holterhus Phone: 0049-(0)431-597-1626  Fax: 0049-(0)431-597-1675  Contact

Prof. Dr. Reiner Siebert Phone: 0049-(0)431-597-1775  Fax: 0049-(0)431-597-1880  Contact

Project Staff

Institute Presentation

The University Hospital of Schleswig Holstein is a clinic of maximum medical care. Emerged from the joining of the University Hospitals of Lübeck and Kiel, it is one of Europe’s largest hospitals. The campus in Kiel is the largest biomedical University campus in Schleswig-Holstein.

In the Division of Pediatric Endocrinology and Diabetes in Kiel (part of the Department of Pediatrics) more than 3000 cases suffering from Pediatric Endocrine diseases are diagnosed and treated annually. One major focus of our group is the diagnosis, treatment and research on developmental disorders caused by hormonal imbalances including DSD. Therefore, a particular DSD team for inter-disciplinary patient management has been established.

The Department of Human Genetics is working closely together with the Division of Pediatric Endocrinology and Diabetes providing the newest high-tech facilities in genome and epigenome research.

The major contribution of our clinic to the European DSD project will be the determination of the impact of DNA methylation for the development of specific DSD-phenotypes in human. These data will provide valuable novel insights into the regulation of human sex development and individual androgenization. In the future, epigenomic markers of prenatal androgen programming may be of help in clinical studies and individual patient counseling with respect to gender.