Molecular Endocrinology & rare diseases
Hospices Civils de Lyon
59 Boulevard Pinel
69677 Bron
France

 www.chu-lyon.fr

Project Leader

Prof. Yves Morel Phone: 0033-(0)472129683  Fax: 0033-(0)4-72129720  Contact

Project Staff

Prof. Marc Nicolino Pediatrician and chief of paediatric endocrinology (Lyon)

Prof. Pierre Chatelain Paediatrician and coordinator of French referral DSD centre

Dr. Véronique Tardy M.D-Molecular biologist/expert in 21-hydroxylase deficiency

Institute Presentation

“Hospices Civils of Lyon” is the second larger hospital in France. Recently all activities in Pediatric, Obstetric-Gynecology and Reproductive Endocrinology have been regrouped on the same site (HFME, Bron-Lyon). Its medical research is closely linked with the Claude-Bernard University of Lyon. During the last 40 years, our team associated with the department of paediatric endocrinology and surgery has greatly contributed to a better knowledge and treatment of DSD, especially for disorders of steroid biosynthesis: normal hormonal values in children (Dr Forest), prenatal treatment to prevent virilization of affected female foetus (Drs Forest and David, 1984). Since 1990, we have developed a network of French paediatric endocrinologists, geneticians, obstetricians and surgeons for hormonal and molecular studies of DSD patients. To date, thanks to this French network, genotyping of two large cohorts have been done by our team: the one including patients with disorders of steroid biosynthesis (especially more than 3000 patients with 21-hydroxylase deficiency), the other of about 800 DSD 46, XY DSD patients. These hormonal and molecular studies are the basis of more extensive studies for a better evaluation of the diagnosis, the management and the treatment of DSD (long-term follow-up, EuroDSD studies for patients without genetic lesions, etc.). Our close collaboration with the French referral clinical centre coordinated by Pierre CHATELAIN is a must to improve the care of patients with DSD.
Current members of our “Molecular Endocrinology and rare diseases involved in DSD" research are: Dr Véronique TARDY (21-hydroxylase deficiency), Drs Delphine MALLET, Ingrid PLOTTON, Faiza CABET, Laurence MICHEL (DSD 46,XY), Dr Ingrid PLOTTON (hormonal investigation).